Whilst very low-rely MBL hardly ever progresses to CLL, large-rely MBL progresses to CLL requiring therapy in a level of one% to 2% every year. Large-depend MBL is distinguished from Rai 0 CLL based on whether or not the B-mobile depend is above or underneath five × 109/L. Though individuals with each substantial-depend MBL and CLL Rai phase 0 are